<Emphasis Type="Italic">TRAF1/C5</Emphasis>polymorphism is not associated with increased mortality in rheumatoid arthritis: two large longitudinal studies |
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| Authors: | Jessica AB van Nies Rute B Marques Stella Trompet Zuzana de Jong Fina AS Kurreeman Rene EM Toes J Wouter Jukema Tom WJ Huizinga Annette HM van der Helm-van Mil |
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| Institution: | (1) Department of Rheumatology, Leiden University Medical Centre, Albinusdreef 2, 2333, ZA, Leiden, The Netherlands;(2) Department of Cardiology, Leiden University Medical Centre, Albinusdreef 2, 2333, ZA, Leiden, The Netherlands;(3) Department of Gerontology and Geriatrics, Leiden University Medical Centre, Albinusdreef 2, 2333, ZA, Leiden, The Netherlands |
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| Abstract: | Introduction Recently an association between a genetic variation in TRAF1/C5 and mortality from sepsis or cancer was found in rheumatoid arthritis (RA). The most prevalent cause of death, cardiovascular
disease, may have been missed in that study, since patients were enrolled at an advanced disease stage. Therefore, we used
an inception cohort of RA patients to investigate the association between TRAF1/C5 and cardiovascular mortality, and replicate the findings on all-cause mortality. As TRAF1/C5 associated mortality may not be restricted to RA, we also studied a large cohort of non-RA patients. |
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