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Matrix metalloproteinase-8 deficiency increases joint inflammation and bone erosion in the K/BxN serum-transfer arthritis model |
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| Authors: | Samuel García Jerónimo Forteza Carlos López-Otin Juan J Gómez-Reino Antonio González Carmen Conde |
| Institution: | 1.Research Laboratory and Rheumatology Unit, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS),SERGAS, Biomedical Research Institute (IDIS),A Coru?a,Spain;2.Department of Pathology, Complexo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS,Biomedical Research Institute (IDIS),A Coru?a,Spain;3.Department of Biochemistry and Molecular Biology,Instituto Universitario de Oncología, Universidad de Oviedo,Oviedo,Spain;4.Department of Medicine,University of Santiago de Compostela,A Coru?a,Spain |
| Abstract: | IntroductionRheumatoid arthritis is an autoimmune disease in which joint inflammation leads to progressive cartilage and bone erosion. Matrix metalloproteinases (MMPs) implicated in homeostasis of the extracellular matrix play a central role in cartilage degradation. However, the role of specific MMPs in arthritis pathogenesis is largely unknown. The aim of the present study was to investigate the role of Mmp-8 (collagenase-2) in an arthritis model. |
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