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Adiponectin may contribute to synovitis and joint destruction in rheumatoid arthritis by stimulating vascular endothelial growth factor, matrix metalloproteinase-1, and matrix metalloproteinase-13 expression in fibroblast-like synoviocytes more than proinflammatory mediators |
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| Authors: | Hyun-Mi Choi Yeon-Ah Lee Sang-Hoon Lee Seung-Jae Hong Dae-Hyun Hahm Sang-Yun Choi Hyung-In Yang Myung Chul Yoo Kyoung Soo Kim |
| Institution: | (1) East-West Bone & Joint Research Institute, East-West Neo Medical Center, Kyung Hee University, 149 Sangil-dong, Gangdong-gu, Seoul, 134-727, Republic of Korea;(2) Division of Rheumatology, Department of Internal Medicine, College of Medicine, Kyung Hee University, Hoegi-1-dong, Dongdaemun-gu, Seoul, 130-702, Republic of Korea;(3) Division of Rheumatology, Department of Internal Medicine, East-West Neo Medical Center, Kyung Hee University, 149 Sangil-dong, Gangdong-gu, Seoul, 134-727, Republic of Korea;(4) Acupuncture and Meridian Science Research Center, Kyung Hee University, Hoeggi-dong, Dongdaemoon-gu, Seoul, 130-702, Republic of Korea;(5) School of Life Sciences and Biotechnology, Anam-dong Seongbuk-gu, Korea University, Seoul, 136-701, Republic of Korea |
| Abstract: | IntroductionThe role of adiponectin in the pathogenesis of arthritis is still controversial. This study was performed to examine whether adiponectin is involved in joint inflammation and destruction in rheumatoid arthritis (RA) in relation to the expression of vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs). |
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