Neutrophils exhibit distinct phenotypes toward chitosans with different degrees of deacetylation: implications for cartilage repair |
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Authors: | Pascale Simard Hugo Galarneau Sébastien Marois Daniel Rusu Caroline D Hoemann Patrice E Poubelle Hani El-Gabalawy Maria JG Fernandes |
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Institution: | 1. Centre de Recherche en Rhumatologie et Immunologie, Centre de Recherche du CHUQ-CHUL, boul. Laurier, Québec, G1V 4G2, Canada 2. Department of Anatomy and Physiology, Université Laval, avenue de la Médecine, Québec, G1V 0A6, Canada 3. Department of Medicine, Université Laval, avenue de la Médecine, Québec, G1V 0A6, Canada 4. Department of Chemical Engineering,Ecole Polytechnique, Institute of Biomedical Engineering, boul. édouard-Montpetit, Montréal, H3C 3A7, Canada 5. Arthritis Centre, University of Manitoba, Sherbrook Street, Winnipeg, R3A 1M4, Canada
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Abstract: | Introduction Osteoarthritis is characterized by the progressive destruction of cartilage in the articular joints. Novel therapies that
promote resurfacing of exposed bone in focal areas are of interest in osteoarthritis because they may delay the progression
of this disabling disease in patients who develop focal lesions. Recently, the addition of 80% deacetylated chitosan to cartilage
microfractures was shown to promote the regeneration of hyaline cartilage. The molecular mechanisms by which chitosan promotes
cartilage regeneration remain unknown. Because neutrophils are transiently recruited to the microfracture site, the effect
of 80% deacetylated chitosan on the function of neutrophils was investigated. Most studies on neutrophils use preparations
of chitosan with an uncertain degree of deacetylation. For therapeutic purposes, it is of interest to determine whether the
degree of deacetylation influences the response of neutrophils to chitosan. The effect of 95% deacetylated chitosan on the
function of neutrophils was therefore also investigated and compared with that of 80% deacetylated chitosan. |
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