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Collagen-specific T-cell repertoire in blood and synovial fluid varies with disease activity in early rheumatoid arthritis |
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| Authors: | Francesco Ria Romina Penitente Maria De Santis Chiara Nicolò Gabriele Di Sante Massimiliano Orsini Dario Arzani Andrea Fattorossi Alessandra Battaglia Gian Franco Ferraccioli |
| Institution: | (1) Institute of General Pathology, Catholic University, 00168 Largo F Vito, Rome, Italy;(2) Department of Rheumatology, Catholic University, CIC, 00168 Via Moscati, Rome, Italy;(3) Institute of Hygiene and Biostatistics, Catholic University, 00168 Largo F Vito, Rome, Italy;(4) Department of Gynecology, Laboratory of Immunology, Catholic University, 00168 Largo F Vito, Rome, Italy |
| Abstract: | IntroductionType II collagen is a DR4/DR1 restricted target of self-reactive T cells that sustain rheumatoid arthritis. The aim of the present study was to analyze the T-cell receptor repertoire at the onset of and at different phases in rheumatoid arthritis. |
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