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Circulating mediators of bone remodeling in psoriatic arthritis: implications for disordered osteoclastogenesis and bone erosion |
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| Authors: | Nicola Dalbeth Bregina Pool Timothy Smith Karen E Callon Maria Lobo William J Taylor Peter B Jones Jillian Cornish and Fiona M McQueen |
| Institution: | (1) Department of Medicine, University of Auckland, 85 Park Rd, Auckland, 1010, New Zealand;(2) Department of Rheumatology, Auckland District Health Board, Greenlane West, Auckland, 1051, New Zealand;(3) Department of Medicine, University of Otago, Wellington, Mein St, Wellington, 6021, New Zealand;(4) Waikato Clinical School, University of Auckland, Pembroke Street, Hamilton, 3240, New Zealand;(5) Department of Molecular Medicine and Pathology, University of Auckland, 85 Park Rd, Auckland, 1010, New Zealand |
| Abstract: | IntroductionDiverse bone pathologies are observed in patients with psoriatic arthritis (PsA). Uncoupling of bone remodeling with disordered osteoclastogenesis has been implicated in the pathogenesis of PsA. The aim of this study was to examine the role of soluble mediators of bone remodeling within the circulation of patients with PsA. |
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