A novel antibiotic produced by <Emphasis Type="Italic">streptomyces noursei</Emphasis> Da07210 |
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| Authors: | Xiaopeng Wu Huiqin Huang Guangying Chen Qianguang Sun Jie Peng Jun Zhu Shixiang Bao |
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| Institution: | (1) Key Laboratory of Tropical Crop Biotechnology, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, People’s Republic of China;(2) Department of Chemistry, Hainan Normal University, Haikou, People’s Republic of China |
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| Abstract: | A novel antibiotic 210-A, named as (6S,8aS,9S,11S,12aR)-6-hydroxy-9,10-dimethyldecahydrobenzod]azecine-2,4,12(3H)-trione, was isolated from the fermentation broth of Streptomyces noursei Da07210, its structure was unambiguously established by spectral analyses and chemical comparison with related cycloheximide.
Experiments demonstrated that 210-A bore strong activity against Fusarium oxysporum f. sp. cubense race four (Foc race four), which also showed antitumor activity against SMMC-7721 human hepatocarcinoma cells and S180 murine
sarcoma, and the IC50 values were 0.77 and 0.74 μg/ml, respectively. |
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| Keywords: | Antifungal activity Fungicide Antitumor activity Actinomycete |
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