Rational design for over-production of desirable microbial metabolites by precision engineering |
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| Authors: | Hong Gao Xianlong Zhou Zhongxuan Gou Ying Zhuo Chengzhang Fu Mei Liu Fuhang Song Elizabeth Ashforth Lixin Zhang |
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| Institution: | (1) Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, People’s Republic of China;(2) Graduate University of Chinese Academy of Sciences, Beijing, People’s Republic of China; |
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| Abstract: | Microbes represent a valuable source of commercially significant natural products that have improved our quality of life.
Precision engineering can be used to precisely identify and specifically modify genes responsible for production of natural
products and improve this production or modify the genes creating products that would not otherwise be produced. There have
been several success stories concerning the manipulation of regulatory genes, pathways, and genomes to increase the productivity
of industrial microbes. This review will focus on the strategies and integrated approaches for precisely deciphering regulatory
genes by various modern techniques. The applications of precision engineering in rational strain improvement also shed light
on the biology of natural microbial systems. |
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