Long-term Clinical Outcome and MIBI SPECT Parameters in Percutaneous Coronary Interventions |
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Authors: | M de Mulder F M van der Zant P Knaapen J H Cornel V A W M Umans |
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Institution: | 1Department of Cardiology, Medical Centre Alkmaar, 1815 JD Alkmaar, the Netherlands ;2Department of Nuclear Medicine, Medical Centre Alkmaar, Alkmaar, the Netherlands ;3Department of Cardiology, VU University Medical Centre, Amsterdam, the Netherlands |
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Abstract: | Background and AimPrimary percutaneous coronary intervention (PCI) is the preferred treatment option for acute myocardial infarction (MI). Off-site PCI reduces time-to-treatment, which could potentially lead to enhanced clinical outcomes. Therefore, we investigated whether off-site PCI improves 5-year clinical outcomes compared with on-site PCI and whether this is related to in-hospital 99mTc-sestamibi single photon emission computed tomography (MIBI SPECT) parameters.MethodsWe describe the 5-year follow-up for a combined endpoint of death or re-infarction in 128 patients with acute MI who were randomly assigned to undergo primary PCI at the off-site centre (n?=?68) or to transferral to an on-site centre (n?=?60). Three days after PCI, MIBI SPECT was performed to estimate infarct size. A multivariate Cox regression model was created to study the relation between MIBI SPECT parameters and long-term clinical outcomes.ResultsAfter a mean follow-up of 5.8?±?1.1 years, 25 events occurred. Off-site PCI significantly reduced door-to-balloon time compared with on-site PCI (94?±?54 versus 125?±?59 min, p?=?0.003). However, infarct size (17?±?15 versus 14?±?12%, p?=?0.34) and 5-year death or infarct rate (21% versus 18%, p?=?0.75) were comparable between treatment centres. With multivariate analysis, only Killip class ≥2 and Q wave MI, but not scintigraphic data, predicted long-term clinical outcomes.ConclusionOff-site PCI reduced door-to-balloon time with a comparable 5-year death or infarct rate. Parameters from resting MIBI SPECT on day 3 after MI did not predict long-term clinical outcomes. |
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Keywords: | Primary angioplasty Myocardial infarction 99mTc-sestamibi SPECT 5-Year clinical outcome |
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