N-terminal brain natriuretic propeptide levels correlate with procalcitonin and C-reactive protein levels in septic patients |
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| Authors: | Mariusz Piechota Maciej Banach Robert Irzmański Małgorzata Misztal Jacek Rysz Marcin Barylski Magdalena Piechota-Urbańska Jan Kowalski Lucjan Pawlicki |
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| Institution: | (1) Department of Anaesthesiology and Intensive Care Unit, Bolesław Szarecki University Hospital No. 5 in Łódź, Medical University of Łódź, Poland;(2) 1st Department of Cardiology and Cardiac Surgery, University Hospital No. 3 in Łódź, Medical University of Łódź, ul. Sterlinga 1/3, 91-425 Łódź, Poland;(3) Department of Internal Diseases and Cardiological Rehabilitation, Bolesłw Szarecki University Hospital No. 5 in łódź, Medical University of łódź, Poland;(4) Department of Statistical Methods, University of łódź, Poland;(5) 2nd Department of Family Medicine, University Hospital No. 2 łódź, Medical University of łódź, Poland;(6) Department of Pharmacy, Medical University of Łódź, Poland |
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| Abstract: | The aim of this study was to find the relationship between N-terminal brain natriuretic propeptide (NT-proBNP), procalcitonin
(PCT) and C-reactive protein (CRP) plasma concentrations in septic patients. This was a prospective study, performed at Medical
University Hospital No. 5 in łódź. Twenty patients with sepsis and severe sepsis were included in the study. N-terminal brain
natriuretic propeptide, procalcitonin and C-reactive protein concentrations, and survival were evaluated. In the whole studied
group (128 measurements), the mean NT-proBNP, procalcitonin and C-reactive protein concentrations were, respectively: 140.80±84.65
pg/ml, 22.32±97.41 ng/ml, 128.51±79.05 mg/l. The correlations for the NT-proBNP level and procalcitonin and C-reactive protein
levels were 0.3273 (p<0.001) and 0.4134 (p<0.001), respectively. NT-proBNP levels correlate with PCT and CRP levels in septic
patients. In the survivor subgroup, the mean NT-proBNP plasma concentrations were significantly lower than in the non-survivor
subgroup. |
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| Keywords: | N-terminal brain natriuretic propeptide Procalcitonin C-reactive protein Sepsis Severe sepsis |
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