| 不同临床类型乙型肝炎血清IgA特异性激活补体类免疫复合物的研究 |
| |
| 引用本文： | 彭宣宪,张建营.不同临床类型乙型肝炎血清IgA特异性激活补体类免疫复合物的研究[J].病毒学报,1993,9(4):325-330. |
| |
| 作者姓名： | 彭宣宪 张建营 |
| |
| 作者单位： | 南昌大学生物科学与工程系，河南医科大学预防医学系，南昌大学医学院，南昌大学生物科学与工程系，南昌大学生物科学与工程系，江西省肿瘤医院，江西省肿瘤医院 330047，330047，330047 |
| |
| 摘 要： |
|
| 关 键 词： | 乙型肝炎 免疫复合物 免疫球蛋白A |
CIRCULATING IgA-SPECIFIC IMMUNE COMPLEX ACTIVATING COMPLEMENT IN DIFFERENT CLINICAL TYPES OF HEPATITIS B INFECTION |
| |
| Peng Xuanxian Zhang Jianying Wan Yage Li Siguang Chen Yanping Huang Zoumei Xu Guangming.CIRCULATING IgA-SPECIFIC IMMUNE COMPLEX ACTIVATING COMPLEMENT IN DIFFERENT CLINICAL TYPES OF HEPATITIS B INFECTION[J].Chinese Journal of Virology,1993,9(4):325-330. |
| |
| Authors: | Peng Xuanxian Zhang Jianying Wan Yage Li Siguang Chen Yanping Huang Zoumei Xu Guangming |
| |
| Institution: | Peng Xuanxian Zhang Jianying Wan Yage Li Siguang Chen Yanping Huang Zoumei Xu GuangmingDepartment of Biological Science and Technology,Nanchang University,Nanchung 330047,PRCDepartment of Epidemiology,Henan Medical University,Zhengzhou 450052,PRC Hospital of Nanchang University,Nanchang 330047,PRC Tumour Hospital of Jiangxi Province,Nanchang 330029,PRC |
| |
| Abstract: | By an complement capture-ELISA method,amounts of circulating IgA specific immune complexes activating complement (IgA/C3-CIC)were exa-mined in different clinical types of hepatitis B infection. The positive rates of IgA/C3-CIC in HBsAg asymptomatic carriers, acute hepaitis B, chronic persistent hepatitis B, chronic active hepatitis B,severe hepatitis B and cirrhosis after hepatitis B were 9.8%, 36.4%, 35.2%,58.2%, 72.2% and 61.5% respectively,showing statistically significant differences between the groups. The positive rates of IgA/C3-CIC were positively related with the degree of liver damage in different types of hepatitis B by Cochran-Armitage's tendency analysis and in chronic active hepatitis B, were sig nificantly higher in the increased ALT group than in the normai ALT group. These results suggest that a cause-effect relationship may exist bet-ween the positive rate of IgA/C3-CIC and liver damage of chronic active hepatitis B. It is concluded that IgA/C3-CIC may be one of the valuable markers in distinguishing different clinical types of hepatitis B from each other, and its pathogenic significance of IgA/C3-CIC should be consi-dered. |
| |
| Keywords: | Hepatitis B Circulating immune complexes Immunoglobu-lin A Complement ELISA |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
