| 从云南省蝙蝠中分离基孔肯雅病毒及血清抗体调查 |
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| 引用本文： | 张海林,刘丽华.从云南省蝙蝠中分离基孔肯雅病毒及血清抗体调查[J].病毒学报,1989,5(1):31-36. |
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| 作者姓名： | 张海林 刘丽华 |
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| 作者单位： | 云南省流行病防治研究所
(张海林，施华芳，自登云，李兆祥，张天寿)，中国药品生物制品检定所
(刘丽华，俞永新，崔五全，王志伟)，云南省景洪县卫生防疫站
(国正鸣，李新年)，云南省景洪县卫生防疫站(甲利) |
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| 摘 要： |
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| 关 键 词： | 基孔肯雅病毒 蝙蝠 血清抗体 |
ISOLATION OF CHIKUNGUNYA VIRUS FROM BAT IN YUNNAN PROVINCE AND SEROLOGICAL INVESTIGATIONS |
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| Zhang Hailin Shi Huafang Liu lihua Yu Yongxin Zi Dengyun Li Zhaoxiang Zhang Tianshou Cui Wuquan Wang Zhiwei Guo Zhenming Li Xinnian Jia Li Yunnan Provincial Institute of Epidemic Diseases Control and Research,DaliNational Institute for the Control of Pharmaceutical and Biological Products,BeijingJinghong County Station of Sanitation and Epidemic Prevention,Jinghong.ISOLATION OF CHIKUNGUNYA VIRUS FROM BAT IN YUNNAN PROVINCE AND SEROLOGICAL INVESTIGATIONS[J].Chinese Journal of Virology,1989,5(1):31-36. |
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| Authors: | Zhang Hailin Shi Huafang Liu lihua Yu Yongxin Zi Dengyun Li Zhaoxiang Zhang Tianshou Cui Wuquan Wang Zhiwei Guo Zhenming Li Xinnian Jia Li Yunnan Provincial Institute of Epidemic Diseases Control and Research DaliNational Institute for the Control of Pharmaceutical and Biological Products BeijingJinghong County Station of Sanitation and Epidemic Prevention Jinghong |
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| Abstract: | In July 1986, a strain of virus was isolated from a pool of brain tissues of bats(Rousettus leschenaulti ) collected from Xishuangbanna area, Yun-nan Province, China. This virus strain could regularly cause illness and death in suckling mice, produced evident CPE in the C6/36 and BHK21 cells. It agglutinated red blood cells of dove, goose and sheep at pH 5.75-6.4. This virus is sensitive to acid and ether but resistant to 5-FduR. It is a RNA virus.This virus has been identified serologically by hemagglutination inhibition ( HI ), immunofluorescent and neutralization tests. It showed specific reaction of high titres to Chikungunya ( CHIK ) viusr only and no reaction with Mayaro, Semliki forest disease, Sindbis, Getah, Sagiyama, M1, Dengue fever and Japanese encephalitis viruses. Therefore it is identified as Chikungunya virus. This is the first report isolation of CHIK vfrus in mainland China.Sera from normal human population and animals in Yunnan were tested for antibodies against CHIK virus by HI test with positive results of 6.93% (70/1010)for man, 2.45% (5/204)for Macaca mullata and 4.06%(8/197) for pigs. These results demonstrated that CHIK virus infection exists in human beings and animals in Yunnan Province. |
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| Keywords: | Chikungunya virus Bat Serological investigation |
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