| 中国和日本分离的几株流行性出血热病毒的抗原性比较 |
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| 引用本文： | 邢峥,宋干,刘为民,郑晓丽,廖化新,傅建林.中国和日本分离的几株流行性出血热病毒的抗原性比较[J].病毒学报,1987(1). |
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| 作者姓名： | 邢峥 宋干 刘为民 郑晓丽 廖化新 傅建林 |
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| 作者单位： | 中国预防医学科学院病毒学研究所
(邢峥，宋干，刘为民，廖化新)，卫生部长春生物制品研究所
(郑晓丽)，中国预防医学科学院病毒学研究所(傅建林) |
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| 摘 要： | 采用间接免疫荧光法(IFA)和ELISA法比较了几株中国和日本流行性出血热病毒(EHFV)的抗原性,IFA法不能区分大鼠属和姬鼠属来源的病毒,ELISA竞争试验表明,大鼠型病毒(R22、SR-11和TR-352株)与姬鼠型病毒(A 9株)存在弱单向交叉反应,交叉ELISA证实,A 9株与R22株、SR-11株和TR-352株均有较显著的抗原性差异,但R22,SR-11和TR-352株彼此间抗原性相近,本文讨论了有关EHFV抗原性比较中的一些问题。
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| 关 键 词： | 流行性出血热病毒 抗原性比较 大鼠型病毒 姬鼠型病毒 |
ANTIGENIC COMPARISON OF VIRUSES OF HEMORRHAGIC FEVER WITH RENAL SYNDROME ISOLATED FROM CHINA AND JAPAN |
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| Xing Zheng Song Gan Liu Weimin Zheng Xiaoli Liao Huaxin Fu Jianlin Hang Changsou.ANTIGENIC COMPARISON OF VIRUSES OF HEMORRHAGIC FEVER WITH RENAL SYNDROME ISOLATED FROM CHINA AND JAPAN[J].Chinese Journal of Virology,1987(1). |
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| Authors: | Xing Zheng Song Gan Liu Weimin Zheng Xiaoli Liao Huaxin Fu Jianlin Hang Changsou |
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| Abstract: | The antigenicity of several viruses of hemorrhagic fever with renal syndrome ( HFRS ) , isolated in China and Japan, was compared by IFA ELI-SA,etc. IFA failed to discriminate the viruses isolated from Apodemus and Rattus. The ELISA competing test indicated a weak one-way cross reaction between Rattus-borne viruses(SR-11 and TR-352 strains ) and Apodemus-bor-ne virus ( A9 strain) .The antigenicity of A9 strain was strikingly different from that of R22,SR-11 and TR-352 strains by cross ELISA, but the Rattus-borne viruses were similar to each other. Some problems concerning the antigenic analysis of HFRS virus were discussed. |
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| Keywords: | Antigenic comparison Hemorrhagic Fever with Renal Syndrome Apodemus serotype Rattus serotype |
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