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1996年延边地区无菌性脑膜脑炎病因病毒的分离及初步鉴定
引用本文:陈立,李玉雨.1996年延边地区无菌性脑膜脑炎病因病毒的分离及初步鉴定[J].病毒学报,1998,14(3):229-233.
作者姓名:陈立  李玉雨
作者单位:[1]中国预防医学科学院病毒学研究所 [2]延边大学医学院
摘    要:吉林省延边地区1996年6月发生无菌性脑膜脑炎流行,在全地区216万人口中,发病人数约5 ̄6千人,死亡2人,为历史上所罕见。从病人脑脊液和粪便标本中分离到多株病毒,分离率较高(分别达到52.4% ̄66.7%)。用WHO提供的RIVM肠道病毒组合血清进行中和定型,不能确定型别。RT-PCR结果表明为肠道病毒。病人早期血清特异性IgM抗性阳性率72.0%,证明所分离的病毒为此次无菌性脑膜脑炎暴发流行的

关 键 词:无菌性脑膜脑炎  肠道病毒  RT-PCR  分离  鉴定

AN ETIOLOGICAL STUDY OF MENINGOENCEPHALITIS WHICH BROKE OUT IN YANBIAN PREFECTURE IN 1996
Chen Li,Li Yuyu,Zheng Hong,Li Zhuxuan,Li Jie,Jiang Xiaohong,Yin Yongri,Li Yingxin,Fang Yong,Zhu shuangli,Zhang Libi.AN ETIOLOGICAL STUDY OF MENINGOENCEPHALITIS WHICH BROKE OUT IN YANBIAN PREFECTURE IN 1996[J].Chinese Journal of Virology,1998,14(3):229-233.
Authors:Chen Li  Li Yuyu  Zheng Hong  Li Zhuxuan  Li Jie  Jiang Xiaohong  Yin Yongri  Li Yingxin  Fang Yong  Zhu shuangli  Zhang Libi
Institution:Chen Li 1 Li Yuyu 2 Zheng Hong 1 Li Zhuxuan 3 Li Jie 1 Jiang Xiaohong 1 Yin Yongri 3 Li Yingxin 2 Fang Yong 1 Zhu shuangli 1 Zhang Libi 1
Abstract:An aseptic meningoencephalitis broke out in Yanbian prefecture of Jilin Province in June,1996.Among 2.16 millions population of Yanbian prefecture,there were about 5 000 patients, and two of the patients died. A total of 23 virus strains were isolated from the cerebrospinal fluid (CSF) and stool specimens of the patients using RD cell, the isolation rate of CSF was 52.4%,that of stool specimens was 68.4%.The isolated viruses could not be typed by neutralization test using the RIVM antiserum provided by WHO.RT-PCR showed the viruses were enteroviruses.The positive rate of patients' acute stage serum IgM antiboudy against the isolated virus was 72.0% by ELISA.The results demonstrate the isolated virus is the pathogen of the aseptic meningoencephalitis, it is an enterovirus, and it may be a new type or a mutated enterovirus strain.The further study about this virus is going on.
Keywords:Aseptic  meningoencephalitis  Enterovirus  RT-PCR
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