| 云南省甲属披膜病毒的特性 |
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| 引用本文： | 徐普庭,王逸民,赵子江,游志勇.云南省甲属披膜病毒的特性[J].病毒学报,1988(4). |
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| 作者姓名： | 徐普庭 王逸民 赵子江 游志勇 |
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| 作者单位： | 中国预防医学科学院病毒学研究所 北京
(徐普庭，王逸民，赵子江)，中国预防医学科学院病毒学研究所 北京(游志勇) |
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| 摘 要： | 从云南省分离的甲属披膜病毒,在蚊、鼠、猴等多种动物细胞和人细胞中均能增殖,并能在营养琼脂覆盖的鸡胚细胞和Vero细胞中形成空斑;在小白鼠体内具有组织泛嗜性;在蔗糖中的浮力密度为1.17g/cm~3。体内外试验都表明,该病毒增殖速度快。用低滴度(4.0 log TCID50)或高滴度(7.0 log TCID50)病毒,脑内或皮下注射乳鼠均能稳定致死,唯低滴度者的潜伏期略长于高滴度者。3周鼠脑内或皮下注射病毒虽不死亡,但在体内能检测出病毒及特异性抗体。
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| 关 键 词： | 甲属披膜病毒 |
CHARACTERIZATION OF NEWLY ISOLATED ALPHAVIRUSES FROM YUNNAN |
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| Xu Puting Wang Yimin Zhao Zijiang You Zhiyong.CHARACTERIZATION OF NEWLY ISOLATED ALPHAVIRUSES FROM YUNNAN[J].Chinese Journal of Virology,1988(4). |
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| Authors: | Xu Puting Wang Yimin Zhao Zijiang You Zhiyong |
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| Abstract: | The alphaviruses isolated in Yunnan Province could readily multiply in several animal cell cultures, such as A,albopictus cells(C6/36), chicken embryo celis ( CEC ), BHK-21, Vero and human embryo celis with CPE, and develop plaques ranged from 0.8-1.2mm in diameter in overlaid CEC and Vero celis. The viruses showed pantropic properties in the infected mice, The buoyant density of the virus in sucrose was 1.17g/cm3. The viruses, either in lower(4.0 log TCID50 ) or in higher(7.0 log TCID50 ) dose, were lethal to suckling mice by intracerebral or subcutaneous injec-tion. The viruses could multiply and induce high titer antibody in three veeks old mice, but did not cause symptoms or lethal effect. |
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| Keywords: | Alphavirus |
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