| 泛素样蛋白ISG15抗病毒机制研究进展 |
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| 引用本文： | 朱紫祥,魏建超,史子学,吴开宝,马志永.泛素样蛋白ISG15抗病毒机制研究进展[J].病毒学报,2012,28(1):78-83. |
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| 作者姓名： | 朱紫祥 魏建超 史子学 吴开宝 马志永 |
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| 作者单位： | 中国农业科学院上海兽医研究所兽医公共卫生学实验室,上海,200241;南京农业大学动物医学院,南京,210095 |
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| 基金项目： | 转基因生物新品种培育科技重大专项(2009ZX08010-022B);上海市基础研究重点项目(10JC1417300) |
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| 摘 要： | ISG15(Interferon stimulated gene 15,ISG15)蛋白是由干扰素诱导产生的一种泛素样蛋白分子,分子量大小约为15kD。ISG15同泛素分子相类似可以被共价结合于其他蛋白分子上,这种现象称为ISG化(ISGylation)现象。ISG化系统包括ISG15、UBE1L、UBCH8和HERC5四类蛋白分子,协同完成ISG化过程。ISG15及ISG化系统在抗病毒反应中具有重要作用。近几年对于ISG15的抗病毒作用和机制的研究已经有了很大的突破,ISG15的抗病毒作用也越来越受到人们重视,了解清楚ISG15抗病毒机制对于研制新的抗病毒药物及提出新的抗病毒策略具有重要意义。本文对ISG15在不同种病毒中的抗病毒机制研究进展进行了简要综述。
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| 关 键 词： | ISG15 ISG化 抗病毒作用 |
Advances in ubiquitin-like protein ISG15-mediated anti-viral response |
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| Zhu Zi-Xiang,Wei Jian-Chao,Shi Zi-Xue,Wu Kai-Bao,Ma Zhi-Yong.Advances in ubiquitin-like protein ISG15-mediated anti-viral response[J].Chinese Journal of Virology,2012,28(1):78-83. |
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| Authors: | Zhu Zi-Xiang Wei Jian-Chao Shi Zi-Xue Wu Kai-Bao Ma Zhi-Yong |
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| Institution: | Department of Veterinary Public Health, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241,China. zzxmailbox@gmail.com |
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| Abstract: | ISG15 is a 15kD ubiquitin-like protein (UBL) induced by interferon (IFN). ISG15 can be covalently attached to proteins, which is called ISGylation process. ISGylation system contains ISG15, UBE1L, UBCH8 and HERC5 proteins, which are all essential for ISGylation. ISG15 and ISGylation system have been found to have anti-viral effects. A better understanding of how ISG15 mediates the anti-viral activity will provide insights for new anti-viral drugs development and new therapeutic strategies. The mechanisms underlying the ISG15 mediated anti-viral response have been explored extensively in recent years. This minireview summarized the research advances of how ISG15 mediated the anti-viral effects against different kinds of viruses. |
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| Keywords: | ISG15 ISGylation Anti-viral effects |
| 本文献已被 CNKI 万方数据 PubMed 等数据库收录！ |
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