1995～2005年中国H3N2亚型人流感病毒血凝素基因变异与流行相关性研究

为了探讨中国H3N2亚型人流感病毒血凝素基因变异与流行关系,对1995～2005年中国分离的550株H3N2流感病毒的HA1序列进行分析.HA1基因进化树显示出以很长的主干和很短的侧枝为特征.HA1的氨基酸位点变异主要位于5个已知的抗原位点及其附近,同时其它位点也有改变.通过对HA1序列资料分析发现这期间导致H3N2流行的序列改变的三种可能,第一种是同时出现多位点变化,第二种是位点变化逐渐发生累积到多个位点变化,第三种是单个抗原位点和受体结合位点同时改变,均可以引起H3N2流行.

Study on the Correlation of Human Influenza A/H3N2 Hemagglutinin Gene Variation and the Epidemic from 1995 to 2005 in China

To study the correlation of human influenza A/H3N2 hemagglutinin gene variation and the epidemic from 1995 to 2005 in China,550 HA1 sequences of H3N2 viruses isolated in China were analyzed with phylogenetic tree.The results showed that the evolution of HA1 represented a long trunk with short side branches.The animo acid changes of HA1 mostly located at the antigenic sites or aside of them,but also may occur at the other sites simultaneously.The analysis also showed three possibilities of HA1 variation to cause H3N2 epidemic,the first is multiple site mutations happened simultaneously;the second is mutation sites happened gradually and then accumulated to multiple sites;the third is a single antigenic site mutation occurred simultaneously with the receptor binding site variation.