| 应用乙型肝炎疫苗阻断围产期乙型肝炎病毒的母婴传播 |
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| 引用本文： | 刘崇柏,朱建会,胡宗汉,宋珍珠,徐志一,李羽,赵凯,巩志立,刘宗芳,翟敏,段恕诚,何南祥,刘丽华,曹文英,沙庆洪,黄爱光,周郎生,孟令先,凌晓明,汪媛.应用乙型肝炎疫苗阻断围产期乙型肝炎病毒的母婴传播[J].病毒学报,1987(1). |
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| 作者姓名： | 刘崇柏 朱建会 胡宗汉 宋珍珠 徐志一 李羽 赵凯 巩志立 刘宗芳 翟敏 段恕诚 何南祥 刘丽华 曹文英 沙庆洪 黄爱光 周郎生 孟令先 凌晓明 汪媛 |
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| 作者单位： | 中国预防医学科学院病毒学研究所
(刘崇柏，朱建会，刘宗芳，翟敏，段恕诚)，卫生部药品生物制品检定所
(胡宗汉，宋珍珠)，上海医科大学
(徐志一)，河南省卫生防疫站
(李羽)，卫生部北京生物制品研究所
(赵凯，巩志立)，浙江医科大学传染病研究所
(何南祥)，四川省卫生防疫站
(刘丽华)，江苏省卫生防疫站
(曹文英)，广东省卫生防疫站
(沙庆洪)，青岛市卫生防疫站
(黄爱光)，浙江省望江山医院
(周郎生)，中国医科大学
(孟令先)，北京市友谊医院
(凌晓明)，中国预防医学科学院病毒学研究所(汪媛) |
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| 摘 要： | 993名HBsAg携带者母亲所生新生儿,以768名新生儿为试验组,226名新生儿为对照组,试验组分别注射HBsAg血源性氢氧化铝佐剂疫苗,乙型肝炎高价免疫球蛋白(HBlg)或疫苗加HBIg,对照组注射安慰剂,所用疫苗为国产81-2、82-1-2、83-1和美国NIHA9,观察表明,出生后六个月,试验组各批疫苗的保护率为60～93％,以83-1批为最高;疫苗加HBIg的保护效果与疫苗相似,HBIg组亦有70％的保护效果,以上结果证明单独应用HBsAg疫苗阻断母婴传播的效果是理想的。
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| 关 键 词： | 乙型肝炎疫苗 围产期传播 乙型肝炎病毒 乙型肝炎高价免疫球蛋白 |
PREVENTION OF PERINATAL TRANSMISSION OF HEPATITIS B VIRUS BY VACCINE AND HBIg IN INFANTS BORN TO HBsAg CARRIER MOTHERS |
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| Abstract: | A double-blind randomized placebo-controlled vaccine trial was undertaken to determine the effect of the formalin inactivated plasma derived hepa-titis B vaccine with aluminium hydroxide as adjuvant in the prevention of antigenemia in infants born to HBsAg carrier mothers.Three batchs of vaccine, produced by the National Vaccine and Serum Institute ( Beijing ) and one batch of NIAID vaccine ( NIH A9 ) , produced by NIAID US, were used. The vaccination procedure was as follows: first injection within the first 24 hrs after delivery and repeated at 1 and 6 months of age.HBIg ( 200-400U/ml ) was given alone at birth and repeated at 2,4 and 6 months, 1 ml for each injection.The result of 768 vaccine recipients followed up for 6 months after birth indicats that the vaccine is highly efficacious. Over all, 20 out of 93 recipients who received vaccine batch 81-2, 29 of 146 recipients who received vaccine 82-1-2, 7 of 120 who received vaccine 83-1 and 5 of 93 who received NIH A9 and 140 of 225 placebo converted to HBsAg positive at 6 month of age.The protective rates were 61%, 72%, 90% and 89% respectively.The protective rate in infants who received HBIg and vaccine was almost the same as in those who received vaccine alone.The protective rate of infants who received HBIg alone was much lower ( 30-69% ) .The data indicates that HBsAg vaccine alone can prevent perinatal transmission of HBV. |
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| Keywords: | Plasma derived hepatitis B vaccine Perinatal transmission Hepatitis B virus Hepatitis B immune globulin |
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