| 甲型流感病毒自然温度敏感株的宿主依赖性 |
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| 引用本文： | 韦北阳,朱既明.甲型流感病毒自然温度敏感株的宿主依赖性[J].病毒学报,1985(3). |
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| 作者姓名： | 韦北阳 朱既明 |
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| 作者单位： | 中国预防医学中心病毒学研究所 北京
(韦北阳)，中国预防医学中心病毒学研究所 北京(朱既明) |
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| 摘 要： | 用鸡胚细胞(CEC)和Madin-Darby Canine Kidney(MDCK)两个宿主细胞系统,检查甲型流感病毒各亚型不同时期流行株的温度敏感性状(ts),发现自然界存在许多宿主依赖的温度敏感性突变株(hd-ts)。它们在CEC上是ts,在MDCK上却是ts~ 。检出的hd-ts株中有些曾经过人体接种观察证明为减毒株。这表明在CEC中鉴定的ts表型与对人减毒性状密切相关。
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| 关 键 词： | 流感病毒 温度敏感株 宿主依赖性 |
HOST DEPENDENCE OF NATURALLY OCCURRING TEMPERATURE-SENSITIVE STRAINS OF INFLUENZA A VIRUS |
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| Wei Beiyang Zhu Jiming.HOST DEPENDENCE OF NATURALLY OCCURRING TEMPERATURE-SENSITIVE STRAINS OF INFLUENZA A VIRUS[J].Chinese Journal of Virology,1985(3). |
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| Authors: | Wei Beiyang Zhu Jiming |
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| Abstract: | A number of naturally occurring host dependent temperature-sensitive strains ( hd-ts ) were discovered by examining influenza A viruses of different subtypes Isolated in different years for temperature-sensitivity by parallel plaque tests in chick embryo cell ( CEC ) and Madin-Darby canine kidney ( MDCK)cell cultures.They were ts in MDCK,but ts in CEC.Some of the hd-ts strains had been confirmed to be of attenuated virulence by adminisiration to humans.This shows that the ts character assayed in CEC is closely related to attenuation for man and hd-ts character may be regarded as a possible marker for the selection of influenza A virus live vaccine strains. |
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| Keywords: | Influenza virus Temperature-sensitive strain Host dependence |
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