| 乌药活性组分LEF的化学成分及抗风湿作用 |
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| 引用本文： | 桂新,李庆林,王峥涛,徐珞珊,徐国钧,中村宪夫,马超美,服部征雄. 乌药活性组分LEF的化学成分及抗风湿作用[J]. 植物资源与环境学报, 1999, 0(4) |
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| 作者姓名： | 桂新 李庆林 王峥涛 徐珞珊 徐国钧 中村宪夫 马超美 服部征雄 |
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| 作者单位： | 中国药科大学生药学研究室!南京210038(桂新，李庆林，王峥涛，徐珞珊，徐国钧)，富山医科药科大学和汉药研究所!日本富山9300194(中村宪夫，马超美，服部征雄) |
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| 基金项目： | 国家“九五”科技攻关项目 !( 96 90 3 0 2 0 3 ) |
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| 摘 要： | 从乌药〔Linderaaggregata(Sims)Kosterm.〕根的镇痛、抗炎活性组分(LEF)中分离得到6个缩合鞣质类化合物,鉴定出其中4个,分别为表儿茶素()epicatechin、表儿茶素()epigallocatechin、procyanidinB2及trimericproanthocyanidin(cinnamtanninsB1),另得到一个黄酮甙,鉴定为橙皮甙hesperidin,以上化合物均为首次从乌药中分离得到。药理实验表明,乌药LEF组分对大鼠佐剂性关节炎有明显的治疗作用,对风寒湿痹证模型大鼠炎性肿胀有明显的对抗效应,能够明显降低模型动物炎性组织渗出液中前列腺素(PGE2)含量,具有良好的抗风湿应用前景
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| 关 键 词： | 乌药 LEF组分 缩合鞣质 佐剂性关节炎 风寒湿痹证 |
Compositions and anti|rheumatism effect of LEF fraction from the root of %Lindera aggregata %(Sims) Kosterm. |
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| Chou Guixin,Li Qinglin,Wang Zhengtao,Xu Luoshan and Xu Guojun. Compositions and anti|rheumatism effect of LEF fraction from the root of %Lindera aggregata %(Sims) Kosterm.[J]. Journal of Plant Resources and Environment, 1999, 0(4) |
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| Authors: | Chou Guixin Li Qinglin Wang Zhengtao Xu Luoshan Xu Guojun |
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| Abstract: | Four condensed tannins, (|)|epicatechin, (|)|epigallocatechin, procyanidin B|2 and trimeric proanthocyanidin (cinnamtanins B-{1}), along with a flavone glucoside hesperidin, were isolated and identified from the LEF fraction of root of %Lindera aggregata %(Sims) Kosterm. Effects of LEF on adjuvant arthritis in rats, swelling caused by wind|cold|damp evils of rat hind paws, and the content of prostaglandin (PGE-{2}) of arthralgia caused by wind|cold|damp evils in rat inflammation tissue were tested. The result suggested that the root of %L. aggregata %have cure function to wind|cold|dampness arthralgia|syndrome. |
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| Keywords: | Lindera aggregata %(Sims) Kosterm. LEF fraction condensed tannins adjuvant arthritis (AA) wind|cold|dampness arthralgia|syndrome |
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