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北柴胡茎叶总黄酮抗流感病毒的作用
引用本文:冯煦,王鸣,赵友谊,单宇,董云发.北柴胡茎叶总黄酮抗流感病毒的作用[J].植物资源与环境学报,2002,11(4):15-18.
作者姓名:冯煦  王鸣  赵友谊  单宇  董云发
作者单位:江苏省中国科学院,植物研究所,江苏省药用植物研究中心,江苏,南京,210014
基金项目:江苏省应用基础研究基金资助项目 (BJ0 0 0 0 3 5 )
摘    要:北柴胡 (BupleurumchinenseDC .)茎叶总黄酮 (TFB) 0 .0 9g kg剂量组对乙型流感病毒 (B 京防 98 76 )感染小鼠具有明显的保护作用 (P <0 .0 5 ) ,0 .0 3g kg和 0 .0 9g kg剂量组能明显降低乙型流感病毒 (B 京防 98 76 )感染小鼠肺指数值 (P <0 .0 5 ,P <0 .0 1) ,肺指数抑制率分别为 2 0 .5 %和 2 5 .4 %。组织病理学检查结果表明 ,TFB各剂量组与模型组比较 ,肺部病变均明显减轻 ,其中以TFB高剂量组肺部总体病变程度最轻 ,疗效最好。

关 键 词:北柴胡茎叶  总黄酮  乙型流感病毒
文章编号:1004-0978(2002)04-0015-04
修稿时间:2002年9月10日

Effects of total flavonoid from the aerial part of Bupleurum chinense DC. on infected mice by influenza virus
FENG Xu,WANG Ming,ZHAO You\|yi,SHAN Yu,DONG Yun\|fa.Effects of total flavonoid from the aerial part of Bupleurum chinense DC. on infected mice by influenza virus[J].Journal of Plant Resources and Environment,2002,11(4):15-18.
Authors:FENG Xu  WANG Ming  ZHAO You\|yi  SHAN Yu  DONG Yun\|fa
Abstract:Total flavonoid from the aerial part of \%Bupleurum chinense \?.(TFB) evidently has an inhibitory effect on influenza virus. The 0.09 g/kg group has an obvious protection to infected mice by the influenza B virus (B/jingfan 98\|76) (\%P\%<0.05). The 0.03 g/kg and 0.09 g/kg groups could remarkablely reduce the value of lung index of infected mice, the inhibitory rates of which are 20.5% and 25.4% respectively (\%P\%<0.05 and \%P\%<0.01). The results of histopathological observation show that, comparing with the model groups, the lung pathological processes of the infected mice all were remarkablely relieved in all of the dosage groups of the total flavonoid, among which the curative effect of the high dosage group (0.09 g/kg) is the most evident.
Keywords:the aerial part of \%Bupleurum chinense \?    total flavonoid  influenza B virus
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