Binding of active and inactive hemolytic factor of sea anemone nematocyst venom to red blood cells |
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Authors: | D A Hessinger H M Lenhoff |
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Institution: | 1. Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92664 USA;2. Department of Developmental and Cell Biology University of California, Irvine, California 92664 USA |
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Abstract: | Sea anemone nematocyst venom, in the presence of Ca2+, induced the lysis of red blood cells after an induction period. In the absence of Ca2+, however, no lysis occurred, but the hemolytic factor was shown to bind to the cells. This binding was shown to be requisite for the Ca2+ dependent lysis to ensue. After freeze thawing, the venom proteins responsible for lysis lost their hemolytic activity, yet still bound to the cells. The freezethawed inactivated venom competitively blocked hemolysis by active venom. |
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Keywords: | To whom inquiries should be addressed Present address: Department of Biology University of South Florida Tampa Florida 33620 |
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