Endothelin-1 inhibits adipogenic differentiation of 3T3-L1 preadipocytes |
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| Authors: | T Tanahashi K Yamaguchi S Ishikawa M Kusuhara I Adachi O Abe |
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| Institution: | Growth Factor Division, National Cancer Center Research Institute, Tokyo, Japan. |
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| Abstract: | The effect of endothelin (ET)-1 on the adipogenic differentiation of 3T3-L1 preadipocytes was examined. Cellular morphology and lipoprotein lipase activity were used as differentiation markers. ET-1 inhibited the hormone-induced adipogenic differentiation of 3T3-L1 preadipocytes morphologically and biochemically in a dose-dependent manner. These findings promote ET-1 as a potent inhibitor of adipogenic differentiation, playing an important role in cellular differentiation of preadipocytes and making it a significant regulator of lipid metabolism. |
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