DNA biosensors based on self-assembled carbon nanotubes |
| |
Authors: | Wang S G Wang Ruili Sellin P J Zhang Qing |
| |
Institution: | Department of Physics, School of Electronics and Physical Sciences, University of Surrey, Guildford GU2 7XH, UK. s.wang@surrey.ac.uk |
| |
Abstract: | DNA biosensors based on self-assembled multi-walled carbon nanotubes (MWNTs) were described in this paper, in which the probe DNA oligonucleotides were immobilized by forming covalent amide bonds between carboxyl groups at the nanotubes and amino groups at the ends of the DNA oligonucleotides. Hybridization between the probe and target DNA oligonucleotides was confirmed by the changes in the voltammetric peak of the indicator of methylene blue. Our results demonstrate that the DNA biosensors based on self-assembled MWNTs had a higher hybridization efficiency compared to those based on random MWNTs. In addition, the developed DNA biosensors also had a high selectivity of hybridization detection. |
| |
Keywords: | DNA biosensors Carbon nanotubes DNA immobilization DNA hybridization efficiency |
本文献已被 ScienceDirect PubMed 等数据库收录! |