TNF superfamily member, TL1A, is a potential mucosal vaccine adjuvant |
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Authors: | Hiroyuki Kayamuro Yasuo Yoshioka Yasuhiro Abe Kazufumi Katayama Kohei Yamashita Tomoaki Yoshikawa Takachika Hiroi Yuichi Kawai Haruhiko Kamada Shin-ichi Tsunoda Yasuo Tsutsumi |
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Institution: | a Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation (NiBio), 7-6-8 Saito-Asagi, Ibaraki, Osaka 567-0085, Japan b Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan c The Center for Advanced Medical Engineering and Informatics, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan d Department of Allergy and Immunology, The Tokyo Metropolitan Institute of Medical Science, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo 113-8613, Japan e Faculty of Pharmaceutical Sciences, Kobe-Gakuin University, 518, Arise, Ikawadani, Nishiku, Kobe 651-2180, Japan |
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Abstract: | The identification of cytokine adjuvants capable of inducing an efficient mucosal immune response against viral pathogens has been long anticipated. Here, we attempted to identify the potential of tumor necrosis factor superfamily (TNFS) cytokines to function as mucosal vaccine adjuvants. Sixteen different TNFS cytokines were used to screen mucosal vaccine adjuvants, after which their immune responses were compared. Among the TNFS cytokines, intranasal immunization with OVA plus APRIL, TL1A, and TNF-α exhibited stronger immune response than those immunized with OVA alone. TL1A induced the strongest immune response and augmented OVA-specific IgG and IgA responses in serum and mucosal compartments, respectively. The OVA-specific immune response of TL1A was characterized by high levels of serum IgG1 and increased production of IL-4 and IL-5 from splenocytes of immunized mice, suggesting that TL1A might induce Th2-type responses. These findings indicate that TL1A has the most potential as a mucosal adjuvant among the TNFS cytokines. |
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Keywords: | Cytokine IgA Mucosal immunity Vaccine |
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