Overexpression of LI-cadherin in gastric cancer is associated with lymph node metastasis |
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Authors: | Ko Samuel Chu Kent-Man Luk John M Wong Bonnie W Yuen Siu-Tsan Leung Suet-Yi Wong John |
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Institution: | Department of Surgery, University of Hong Kong Medical Center, Queen Mary Hospital, Hong Kong. |
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Abstract: | Gastric cancer remains the second leading cause of cancer deaths worldwide. Patients usually present late with local invasion or metastatic diseases. The present study investigated the expression level of liver-intestine cadherin (LI-cadherin) by RT-PCR and its correlation with clinicopathological data in 71 pairs of tumor and non-cancerous gastric mucosa. Protein expression level of LI-cadherin was determined by Western blotting and immunohistochemistry. The mRNA of LI-cadherin was highly expressed in tumor as compared to non-cancerous mucosa. Lymph node metastasis was significantly associated with the expression of LI-cadherin (p=0.038). On multivariate analysis, T staging and LI-cadherin expression were found to be independent factors associated with lymph node metastasis. |
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Keywords: | Gastric adenocarcinoma LI-cadherin Lymph node metastasis Tumor marker |
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