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Overexpression of LI-cadherin in gastric cancer is associated with lymph node metastasis
Authors:Ko Samuel  Chu Kent-Man  Luk John M  Wong Bonnie W  Yuen Siu-Tsan  Leung Suet-Yi  Wong John
Institution:Department of Surgery, University of Hong Kong Medical Center, Queen Mary Hospital, Hong Kong.
Abstract:Gastric cancer remains the second leading cause of cancer deaths worldwide. Patients usually present late with local invasion or metastatic diseases. The present study investigated the expression level of liver-intestine cadherin (LI-cadherin) by RT-PCR and its correlation with clinicopathological data in 71 pairs of tumor and non-cancerous gastric mucosa. Protein expression level of LI-cadherin was determined by Western blotting and immunohistochemistry. The mRNA of LI-cadherin was highly expressed in tumor as compared to non-cancerous mucosa. Lymph node metastasis was significantly associated with the expression of LI-cadherin (p=0.038). On multivariate analysis, T staging and LI-cadherin expression were found to be independent factors associated with lymph node metastasis.
Keywords:Gastric adenocarcinoma  LI-cadherin  Lymph node metastasis  Tumor marker
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