Effect of visible light on the mitochondrial inner membrane. |
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Authors: | B B Aggarwal Y Avi-Dor H M Tinberg L Packer |
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Institution: | 1. Membrane Bioenergetics Group, University of California, Berkeley, CA 94720 USA;2. Physiology Research, V.A. Hospital, Martinez, CA 94553 USA |
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Abstract: | Exposure of mitochondria to visible light in the presence of riboflavin resulted in the initial release of respiratory control, followed by inhibition of electron transport and dissolution of structural integrity. Under these conditions, however, cytochrome c oxidase activity remained unchanged. ATPase activity was stimulated initially and remained in this activitated state even under continued illumination. In submitochondrial preparations, both electron transport and ATPase declined as a function of illumination time; cytochrome c oxidase was not sensitive to light. Enzyme inactivation also occurred to a lesser extent in the absence of riboflavin. |
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Keywords: | (submitochondrial preparations) TMPD (N N N′N′ tetramethyl-p-phenylenediamine) |
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