Melanins production from enkephalins by tyrosinase. |
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Authors: | M A Rosei L Mosca C De Marco |
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Institution: | Dipartimento di Scienze Biochimiche, Università La Sapienza, Rome, Italy. |
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Abstract: | Leu-enkephalin and Met-enkephalin are oxidized in vitro by mushroom and sepia tyrosinase giving rise to synthetic melanins whose production is dependent on incubation time and on enzyme concentration. The Enk-melanins formed are acid-insoluble brownish or reddish pigments showing a continuous absorbance in the visible region when dissolved in basic solution. The presence of the amino acid chain makes them fully soluble in pH 7.4 0.05 M phosphate buffer and methanol. |
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