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Contribution of IPS-1 to polyI:C-induced cytokine production in conjunctival epithelial cells

Authors:	Ueta Mayumi Kawai Taro Yokoi Norihiko Akira Shizuo Kinoshita Shigeru

Institution:	^aDepartment of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan;^bResearch Center for Inflammation and Regenerative Medicine, Faculty of Life and Medical Sciences, Doshisha University, Kyoto, Japan;^cDepartment of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan

Abstract:

Keywords:	Abbreviations: IFN interferon IPS-1 IFN-β promoter stimulator-1 PAMPs pathogen-associated molecular patterns TLRs Toll-like receptors RIG-I retinoic acid-inducible gene-I RLRs retinoic acid-inducible gene-I-like receptors NOD nucleotide-binding oligomerization domain NLRs nucleotide-binding oligomerization domain-like receptors polyI:C polyinosinic:polycytidylic acid PHCjECs primary human conjunctival epithelial cells CXCL chemokine (C&ndash X&ndash C motif) ligand CCL chemokine (C&ndash C motif) ligand MDA5 melanoma-differentiation-associated gene 5 TSLP thymic stromal lymphopoietin ICAM-1 intercellular adhesion molecule-1 Rsad2 radical S-adenosyl methionine domain containing 2 Cmpk2 cytidine monophosphate (UMP-CMP) kinase 2 mitochondrial Mx myxovirus (influenza virus) resistance Ifi44 interferon-induced protein 44 Ifi203 interferon-activated gene 203 Iigp2 interferon-inducible GTPase 2 Rtp4 receptor transporter protein
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