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Altered SK3/KCa2.3-mediated migration in adenomatous polyposis coli (Apc) mutated mouse colon epithelial cells |
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| Authors: | Marie Potier Truong An Tran Aurelie Chantome Virginie Joulin Christophe Vandier Fabrice Pierre |
| Institution: | a Inserm U921, Nutrition Croissance et Cancer, 10 Boulevard Tonnelle, 37032 Tours Cedex, France b Inserm U619, Hôpital Bretonneau, 2 Boulevard Tonnelle, 37044 Tours Cedex 9, France c CNRS-FRE 2939, Institut Gustave Roussy, 94805 Villejuif, France d Université de Toulouse, UMR1089 Xenobiotiques, INRA, ENVT, 23 chemin des Capelles, 31076 Toulouse, France |
| Abstract: | Lost of adenomatous polyposis coli gene (Apc) disturbs the migration of intestinal epithelial cells but the mechanisms have not been fully characterized. Since we have demonstrated that SK3/KCa2.3 channel promotes cancer cell migration, we hypothesized that Apc mutation may affect SK3/KCa2.3 channel-mediated colon epithelial cell motility. We report evidence that SK3/KCa2.3 channel promotes colon epithelial cells motility. Following Apc mutation SK3/KCa2.3 expression is largely reduced leading to a suppression of the SK3/KCa2.3 channel mediated-cell migration. Our findings reveal a previously unknown function of the SK3/KCa2.3 channel in epithelial colonic cells, and suggest that Apc is a powerful regulator SK3/KCa2.3 channel. |
| Keywords: | Apc adenomatous polyposis coli sK3 small-conductance Ca2+-activated K+ channel isoform 3 |
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