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Simvastatin lowers reactive oxygen species level by Nrf2 activation via PI3K/Akt pathway |
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| Authors: | Dionysios Chartoumpekis Panos G Ziros Agathoklis Psyrogiannis |
| Institution: | a Department of Internal Medicine, School of Medicine, University of Patras, 26500 Patras, Greece b Department of Biological Chemistry, University of Athens Medical School, 11527 Athens, Greece |
| Abstract: | |
| Keywords: | HMG-CoA 3-hydroxy-3-methyl-glutaryl-CoA Nrf2 NF-E2-related factor 2 ROS reactive oxygen species Keap1 Kelch-like ECH associating protein ARE antioxidant response element FBS fetal bovine serum MEF mouse embryonic fibroblast WT wild type KO knock out CM-H2DCFDA 5-(and-6)-chloromethyl-2&prime 7&prime -dichlorodihydrofluorescein diacetate acetyl ester |
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