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Isolation and characterization of a human interleukin 2 gene |
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| Authors: | S Mita S Maeda K Obaru N Nishino K Shimada T Hirano K Onoue T Ogawa H Ogawa |
| Institution: | 1. Department of Biochemistry, Kumamoto University School of Medicine, Honjo, Kumamoto 860, Japan;2. Department of Biochemistry, Institute for Medical Immunology, Kumamoto University School of Medicine, Honjo, Kumamoto 860, Japan;3. Department of Biology, Faculty of Science Osaka University, Toyonaka, Osaka 560, Japan |
| Abstract: | An interleukin 2 (IL-2) gene was isolated from a Charon 4A human gene library. Electron microscopic examination of 15 heteroduplexes formed between the genomic DNAs and the IL-2 cDNAs demonstrated that the size of the IL-2 gene is about 5.1 +/- 0.5 kb and that there are at least two introns in this gene. Nucleotide sequence of the 5' flanking region of the IL-2 gene showed a homology with that of the corresponding region of the human immune interferon gene. |
| Keywords: | cDNA complementary DNA mRNA messenger RNA IL-2 interleukin 2 T-cell thymus-derived cell PHA phytohemagglutinin IFN-γ immune interferon IFN-α leukocyte interferon kb kilobase pairs bp base pairs |
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