Antioxidant effects of an aqueous extract of Ilex paraguariensis |
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Authors: | Schinella G R Troiani G Dávila V de Buschiazzo P M Tournier H A |
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Institution: | Cátedra de Farmacología, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, CIC Pcia. de Buenos Aires, 60 y 120, La Plata Buenos Aires, 1900, Argentina. |
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Abstract: | In this work we investigate the antioxidant properties of an aqueous extract prepared from an infusion of Ilex paraguariensis (Aquifoliaceae) using free radical-generating systems. The extract inhibited the enzymatic and nonenzymatic lipid peroxidation in rat liver microsomes in a concentration-dependent fashion, with IC(50) values of 18 microg/ml and 28 microg/ml, respectively. The extract also inhibited the H(2)O(2)-induced peroxidation of red blood cell membranes with an IC(50) of 100 microg/ml and exhibited radical scavenging properties toward superoxide anion (IC(50) = 15 microg/ml) and 2,2-diphenyl-1-picrylhydrazyl radical. In the range of concentrations used, the extract was not a scavenger of the hydroxyl radical. Our results suggest that ingestion of extracts of Ilex paraguariensis could contribute to increase the antioxidant defense of an organism against free radicals attack. |
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