miR-21 coordinates tumor growth and modulates KRIT1 levels |
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Authors: | Francesca Orso Fiorella Balzac Marco Marino Antonio Lembo Saverio Francesco Retta Daniela Taverna |
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Institution: | 1. Molecular Biotechnology Center (MBC), University of Torino, Torino, Italy;2. Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy;3. Center for Complex Systems in Molecular Biology and Medicine, University of Torino, Torino, Italy;4. Department of Clinical and Biological Sciences, University of Torino, Torino, Italy |
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Abstract: | miR-21 is overexpressed in tumors and it displays oncogenic activity. Here, we show that expression of miR-21 in primary tumors anticorrelates with KRIT1/CCM1, an interacting partner of the Ras-like GTPase Rap1, involved in Cerebral Cavernous Malformations (CCM). We present evidences that miR-21 silences KRIT1 by targeting its mRNA 3′UTR and that this interaction is involved in tumor growth control. In fact, miR-21 over-expression or KRIT1 knock-down promote anchorage independent tumor cell growth compared to controls, whereas the opposite is observed when anti-miR-21 or KRIT1 overexpression are employed. Our findings suggest that miR-21 promotes tumor cell growth, at least in part, by down-modulating the potential tumor suppressor KRIT1. |
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Keywords: | KRIT1 miR-21 Tumor growth |
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