Flavonoid B-ring chemistry and antioxidant activity: fast reaction kinetics |
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Authors: | Sekher Pannala A Chan T S O'Brien P J Rice-Evans C A |
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Institution: | Wolfson Centre for Age Related Diseases, GKT School of Biomedical Sciences, King's College London, St. Thomas's Street, London, SE1 9RT, United Kingdom. |
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Abstract: | Rapid scavenging of the model stable radical cation, ABTS(*+), has been applied to screen for the antioxidant activity of flavonoids. The reaction follows two distinct phases. For compounds with a monophenolic B-ring there is a rapid initial phase of reduction of ABTS(*+) within 0.1 s with no further change in the subsequent 2.9 s. In contrast, compounds with a catechol-containing B ring follow a fast initial scavenging phase with a slow secondary phase. Flavonoids with an unsubstituted B ring do not react within this time scale. The findings suggest that the structure of the B ring is the primary determinant of the antioxidant activity of flavonoids when studied through fast reaction kinetics. |
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