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Using F0F1-ATPase motors as micro-mixers accelerates thrombolysis |
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| Authors: | Tao Ning Cheng Jie Yue Jiachang |
| Institution: | a The National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Datun Road 15, Chaoyang District, Beijing 100101, China b School of Public Health , Wuhan University, Wuhan 430072, China c Graduate School of the Chinese Academy of Sciences, Beijing 100101, China |
| Abstract: | We have developed a novel micro-mixer using a biological molecular ATP motor. The micro-mixer was constructed from arrays of chromatophore-embedded δ-free F0F1-ATPases, where the δ-free F1 part acted as a rotator to mix solutions, and the F0 part was driven by light. Confocal microscope studies indicated that the micro-mixer did not touch directly on the fibrin labeled with FITC. The nanomechanical force generated by the motor induced drug movement in the solution and accelerated the fibrinolysis process. All results strongly suggest that the micro-mixers generated a nanomechanical force which accelerated the fibrinolysis process in the presence of lower concentrations of lumbrokinase. |
| Keywords: | F0F1-ATPase Molecular motors Micro-mixers Thrombolysis |
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