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GCN5 regulates the activation of PI3K/Akt survival pathway in B cells exposed to oxidative stress via controlling gene expressions of Syk and Btk |
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| Authors: | Kikuchi Hidehiko Kuribayashi Futoshi Takami Yasunari Imajoh-Ohmi Shinobu Nakayama Tatsuo |
| Institution: | aSection of Biochemistry and Molecular Biology, Department of Medical Sciences, Miyazaki Medical College, University of Miyazaki, Kiyotake, Miyazaki 889-1692, Japan;bDepartment of Biochemistry, Kawasaki Medical School, Kurashiki, Okayama 701-0192, Japan;cMedical Proteomics Laboratory, Graduate School of Frontier Sciences, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan |
| Abstract: | |
| Keywords: | Abbreviations: AKT acutely transforming retrovirus AKT8 in rodent T cell lymphoma BCR B cell receptor Btk Bruton&rsquo s tyrosine kinase ChIP chromatin immunoprecipitation GCN5 general control non-depressible 5 H2O2 hydrogen peroxide HAT histone acetyltransferase HDAC histone deacetylase p-Akt phospho-Akt PI3K phosphatidylinositol 3-kinase PMA phorbol 12-myristate 13-acetate PVDF polyvinyliden difluoride ROS reactive oxygen species SHIP SH2-containing inositol 5-phosphatase Syk spleen tyrosine kinase |
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