Central cholinergic signal-mediated neuroendocrine regulation of vasopressin and oxytocin in ovine fetuses |
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Authors: | Lijun Shi Caiping Mao Fanxing Zeng Yuying Zhang Zhice Xu |
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Institution: | (1) Department of Human Sport Science, Beijing Sport University, Beijing, 100084, PR China;(2) Perinatal Biology Center, Soochow University School of Medicine, Suzhou, 215007, PR China;(3) Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, California 92350, USA |
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Abstract: | Background The hypothalamic-neurohypophysial system plays a fundamental role in the maintenance of body fluid homeostasis by secreting
arginine vasopressin (AVP) and oxytocin (OT) in response to a variety of signals, including osmotic and nonosmotic stimuli.
It is well established that central cholinergic mechanisms are critical in the regulation of cardiovascular responses and
maintenance of body fluid homeostasis in adults. Our recent study demonstrated that intracerebroventricular (i.c.v.) injection
of carbachol elicited an increase of blood pressure in the near-term ovine fetuses. However, in utero development of brain cholinergic mechanisms in the regulation of the hypothalamic neuropeptides is largely unknown. This
study investigated AVP and OT neural activation in the fetal hypothalamus induced by central carbachol. |
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