Novel splice variants associated with one of the zebrafish <Emphasis Type="Italic">dnmt3</Emphasis>genes |
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| Authors: | Tamara?HL?Smith Christine?C?Dueck Aizeddin?A?Mhanni Email author" target="_blank">Ross?A?McGowanEmail author |
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| Institution: | (1) Dept. of Biochemistry, Memorial University, St. John's, NL, Canada;(2) Faculty of Medicine, University of Manitoba, Winnipeg, MB, Canada;(3) Department of Pediatrics & Child Health and Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, MB, Canada |
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| Abstract: | Background DNA methylation and the methyltransferases are known to be important in vertebrate development and this may be particularly
true for the Dnmt3 family of enzymes because they are thought to be the de novo methyltransferases. Mammals have three Dnmt3 genes; Dnmt3a, Dnmt3b, and Dnmt3L, two of which encode active enzymes and one
of which produces an inactive but necessary cofactor. However, due to multiple promoter use and alternative splicing there
are actually a number of dnmt3 isoforms present. Six different dnmt3 genes have recently been identified in zebrafish. |
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