Alterations in high-affinity binding characteristics and levels of opioids in invertebrate ganglia during aging: Evidence for an opioid compensatory mechanism |
| |
Authors: | Amy Chapman Gonzalo Gonzales Wayne R Burrowes Paul Assanah Bernadette Iannone Michael K Leung George B Stefano |
| |
Institution: | 1. Department of Biological Sciences, SUNY/College at Old Westbury, 11568, Old Westbury, New York, USA 2. Department of Chemistry, SUNY/College at Old Westbury, 11568, Old Westbury, New York, USA
|
| |
Abstract: | In Mytilus and Leucophaea the high-affinity binding site density is significantly lower in old animals than in young animals, whereas the low-affinity site density remains unchanged. In Mytilus the estimated met-enkephalin and met-enkephalin-Arg6-Phe7 levels are significantly higher in old than in young animals. In Leucophaea only the met-enkephalin level can be determined, and it is also higher in old animals. The decrease in the high-affinity binding site density and the corresponding increase in endogenous enkephalin levels suggest the existence of an opioid compensatory mechanism associated with the aging process. In Mytilus there is a demonstrated decrease with age in intraganglionic dopamine levels in response to applied opiates. In addition, the inhibition of dopamine-stimulated adenylate cyclase activity by opiates also decreases in older animals. In Leucophaea the sex difference in opioid binding densities diminishes with age. |
| |
Keywords: | |
本文献已被 PubMed SpringerLink 等数据库收录! |
|