Functional domains of the gonadotropin-releasing hormone receptor |
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| Authors: | Stuart C Sealfon Robert P Millar |
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| Institution: | (1) Fishberg Research Center for Neurobiology and Department of Neurology, Mount Sinai School of Medicine, 10029 New York, New York;(2) MRC Regulatory Peptides Research Unit, Department of Chemical Pathology, University of Cape Town Medical School, South Africa |
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| Abstract: | Summary 1. The cloning of the mammalian gonadotropin-releasing hormone receptor sets the stage for rapid progress in understanding the structure of the receptor, its interaction with ligand, and its mechanisms of activation.2. The receptor is a 327 to 328-amino acid seven-transmembrane domain G protein-coupled receptor.3. Recent site-direct mutagenesis studies have provided considerable insight into glycosylation of the receptor, the arrangement of the helices, and the ligand binding domains. |
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| Keywords: | cDNA gene structure mutagenesis receptor model binding site |
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