A cellular automata model for simulating fed-batch penicillin fermentation process |
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Authors: | Yu Naigong and Ruan Xiaogang |
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Institution: | (1) Electronic Information and Control Engineering College, Beijing University of Technology, Beijing, 100022, China |
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Abstract: | A cellular automata model to simulate penicillin fed-batch fermentation process (CAPFM) was established in this study, based
on a morphologically structured dynamic penicillin production model, that is in turn based on the growth mechanism of penicillin
producing microorganisms and the characteristics of penicillin fed-batch fermentation. CAPFM uses the three-dimensional cellular
automata as a growth space, and a Moore-type neighborhood as the cellular neighborhood. The transition rules of CAPFM are
designed based on mechanical and structural kinetic models of penicillin batch-fed fermentation processes. Every cell of CAPFM
represents a single or specific number of penicillin producing microorganisms, and has various state. The simulation experimental
results show that CAPFM replicates the evolutionary behavior of penicillin batch-fed fermentation processes described by the
structured penicillin production kinetic model accordingly.
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Translated from ACTA BIOPHYSICA, 2005, 21(2) 译自: 生物物理学报, 2005,21(2)] |
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Keywords: | penicillin fermentation process fermentation dynamics morphologically structured model cellular automata model |
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