苦槛蓝叶中的黄酮类化合物

为了解苦槛蓝(Myoporum bontioides A.Gray)的化学成分,采用色谱分离技术从苦槛蓝叶片中分离得到11个黄酮类化合物。通过波谱分析,他们的结构分别鉴定为:桔皮素(1)、甜橙素(2)、5,4′-二羟基-6,7,8,3′-四甲氧基黄酮(3)、4′,5,7,8-四甲氧基黄酮(4)、去甲基川陈皮素(5)、5-羟基-6,7,3′,4′-四甲氧基黄酮(6)、3′,4′,5,6,7,8-六甲氧基黄酮(7)、二氢山柰酚(8)、木犀草素(9)、3′,4′,5,7-四羟基-3-甲氧基黄酮(10)和芹黄素(11)。除化合物9之外,其他化合物均为首次从苦槛蓝叶片中分离得到。孢子萌发法测定结果表明,化合物1,2,8和9对香蕉炭疽菌(Colletotrichum musae)具有较好的抑菌活性。这为苦槛蓝叶片中有效成分的利用提供了理论依据。

Flavonoids from the Leaves of Myoporum bontioides

In order to understand the chemical constituents extracted from Myoporum bontioides A. Gray, eleven flavonoid compounds were isolated from the leaves of M. bontioides by chromatographic separation methods. On the basis of spectral data, they were identified as tangeretin (1), sinensetin (2), 5,4'-dihydroxy-6,7,8,3'-tetramethoxyflavone (3), 4',5,7,8-pentamethoxyflavone (4), 5-demethylnobiletin (5), 5-hydroxy- 6,7,3',4'-tetramethoxyflavone (6), nobiletin (7), dihydrokaempferol (8), luteolin (9), 3-methoxy-3',4',5,7- tetrahydroxyflavone (10), and apigenin (11). All these compounds were obtained from M. bontioides for the first time except compound 9. The compounds 1, 2, 8 and 9 had strong antifungal activity against Colletotrichum musae by using spore germination inhibition assay. So, these could provide a theoretical basis for utilizing the active ingredients in leaves of M. bontioides.