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| 酒饼簕根中的细胞毒活性成分 | |
| 引用本文： | 杨涛,梅文莉,曾艳波,左文健,董文化,戴好富.酒饼簕根中的细胞毒活性成分[J].热带亚热带植物学报,2012,20(4):407-412. |
| 作者姓名： | 杨涛 梅文莉 曾艳波 左文健 董文化 戴好富 |
| 作者单位： | 1. 海南大学园艺园林学院,海口570228 2. 中国热带农业科学院热带生物技术研究所,海南省黎药资源天然产物研究与利用重点实验室,海口571101 3. 海口市热带天然产物研究与利用重点实验室,海口571101 |
| 基金项目： | 中国热带农业科学院中央级公益性科研院所基本科研业务费专项(ITBBZD0742)资助 |
| 摘 要： | 用色谱技术从酒饼簕Atalantia buxifolia(Poir.)Oliv.]根的乙醇提取物中分离得到9个化合物,经波谱分析与文献数据对照,分别鉴定为buxifoliadineA(1)、1,3-dihydroxy-2,4-diprenylacridone(2)、5-hydroxy-N-methylseverifoline(3)、buxifoliadine B(4)、N-methylatalaphylline(5)、atalaphylline(6)、东风桔碱(7)、葡萄内酯(8)和松柏醛(9)。化合物9为首次从酒饼簕根中分离得到。细胞毒活性测试结果表明,化合物1和8对人肝癌细胞(SMMC-7721)具有细胞毒活性,化合物3对慢性髓原白血病细胞(K562)的增殖显示了较强的生长抑制活性。 |
| 关 键 词： | 芸香科 酒饼簕 化学成分 吖啶酮生物碱 细胞毒活性 |
| 收稿时间： | 2011/10/17 0:00:00 |
| 修稿时间： | 2011/12/20 0:00:00 |
Cytotoxic Components from the Roots of Atalantia buxifolia (Poir.) Oliv. |
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| YANG Tao,MEI Wen-li,ZENG Yan-bo,ZUO Wen-jian,DONG Wen-hua and DAI Hao-fu.Cytotoxic Components from the Roots of Atalantia buxifolia (Poir.) Oliv.[J].Journal of Tropical and Subtropical Botany,2012,20(4):407-412. | |
| Authors: | YANG Tao MEI Wen-li ZENG Yan-bo ZUO Wen-jian DONG Wen-hua and DAI Hao-fu |
| Institution: | 1. Horticultural and Garden College, Hainan University, China;Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Scienc;1. Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, China;2. Haikou Key Laboratory for Research and Develop;1. Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, China;2. Haikou Key Laboratory for Research and Develop;1. Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, China;2. Haikou Key Laboratory for Research and Develop;1. Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, China;2. Haikou Key Laboratory for Research and Develop;1. Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, China;2. Haikou Key Laboratory for Research and Develop |
| Abstract: | Nine compounds were isolated from the ethanolic extract of roots of Atalantia buxifolia (Poir.) Oliv. by means of chromatographic technology. On the basis of spectral data, their structures were identified as buxifoliadine A (1), 1,3-dihy-droxy-2,4-diprenylacridone (2), 5-hydroxy-N-methylseverifoline (3), buxifoliadine B (4), N-methylatalaphylline (5), atalaphylline (6), atalafoline (7), aurapten (8), and coniferyl aldehyde (9). Compound 9 was isolated from the roots of A. buxifolia for the first time. Compounds 1 and 8 showed cytotoxic activities towards human hepatoma (SMMC-7721), and compound 3 showed significant inhibitory activity towards chronic myelogenous leukemia (K562). |
| Keywords: | Rutaceae Atalantia buxifolia (Poir ) Oliv Chemical constituent Acridone alkaloid Cytotoxicity |
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