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柯拉斯那沉香的生物活性成分研究
引用本文:杨洋,梅文莉,董文化,李薇,王军,王红妮,陈志宝,戴好富.柯拉斯那沉香的生物活性成分研究[J].热带亚热带植物学报,2016,24(5):577-583.
作者姓名:杨洋  梅文莉  董文化  李薇  王军  王红妮  陈志宝  戴好富
作者单位:1. 黑龙江八一农垦大学生命科学技术学院, 黑龙江 大庆 163319;2. 中国热带农业科学院热带生物技术研究所, 农业部热带作物生物学与遗传资源利用重点实验室, 海口 571101,中国热带农业科学院热带生物技术研究所, 农业部热带作物生物学与遗传资源利用重点实验室, 海口 571101,中国热带农业科学院热带生物技术研究所, 农业部热带作物生物学与遗传资源利用重点实验室, 海口 571101,中国热带农业科学院热带生物技术研究所, 农业部热带作物生物学与遗传资源利用重点实验室, 海口 571101,中国热带农业科学院热带生物技术研究所, 农业部热带作物生物学与遗传资源利用重点实验室, 海口 571101,中国热带农业科学院热带生物技术研究所, 农业部热带作物生物学与遗传资源利用重点实验室, 海口 571101,黑龙江八一农垦大学生命科学技术学院, 黑龙江 大庆 163319,中国热带农业科学院热带生物技术研究所, 农业部热带作物生物学与遗传资源利用重点实验室, 海口 571101
基金项目:公益性行业(农业)科研专项(201303117);海南省自然科学基金项目(20168367);海南省工程技术研究中心建设专项(gczx2015005);海南省科协青年科技英才学术创新计划项目(HAST201628)资助
摘    要:为了解柯拉斯那(Aquilaria crassna)的化学成分,从其所产沉香中分离得到10个化合物,经波谱分析分别鉴定为:6,8-羟基-2-(2-苯乙基)色酮(1),6,8-二羟基-2-2-(4-甲氧基苯)乙基]色酮(2),rel-(1a R,2R,3R,7b S)-1a,2,3,7b-tetrahydro-2,3-dihydroxy-5-(2-phenylethyl)-7H-oxirenof]1]benzopyran-7-one(3),rel-(1a R,2R,3R,7b S)-1a,2,3,7b-tetrahydro-2,3-dihydroxy-2-(4-methoxyphenyl)-ethyl]-7H-oxirenof]1]benzopyran-7-one(4),rel-(1a R,2R,3R,7b S)-1a,2,3,7b-tetrahydro-2,3-dihydroxy-5-2-(3-hydroxy-4-methoxyphenyl)-ethyl]-7H-oxirenof]1]benzopyran-7-one(5),oxidoagarochromone B(6),oxidoagarochromone C(7),(5S,6R,7S,8R)-2-2-(3′-hydroxy-4′-methoxyphenyl)ethyl]-5,6,7,8-tetrahydroxy-5,6,7,8-tetrahydrochromone(8),6,7-cis-dihydroxy-2-(2-phenylethyl)-5,6,7,8-tetrahydrochromone(9),N-trans-feruloyltyramine(10)。化合物3~5和8~10为首次从柯拉斯那沉香中分离得到。化合物1,3,6,7,9和10对乙酰胆碱酯酶具有一定的抑制活性,化合物4对人慢性髓原白血病细胞株K-562和人胃癌细胞株SGC-7901均具有较小的抑制作用,化合物1和3对人肝癌细胞株BEL-7402也有抑制活性。

关 键 词:沉香  柯拉斯那  化学成分  细胞毒活性  乙酰胆碱酯酶抑制活性
收稿时间:2016/5/10 0:00:00
修稿时间:6/8/2016 12:00:00 AM

Bioactive Components from Agarwood Originating from Aquilaria crassna
YANG Yang,MEI Wen-li,DONG Wen-hu,LI Wei,WANG Jun,WANG Hong-ni,CHEN Zhi-bao and DAI Hao-fu.Bioactive Components from Agarwood Originating from Aquilaria crassna[J].Journal of Tropical and Subtropical Botany,2016,24(5):577-583.
Authors:YANG Yang  MEI Wen-li  DONG Wen-hu  LI Wei  WANG Jun  WANG Hong-ni  CHEN Zhi-bao and DAI Hao-fu
Institution:1. College of life science and technology, Heilongjiang Bayi Agricultural University, Daqing 163319, Helongjiang, China;2. Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China,Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China,Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China,Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China,Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China,Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China,College of life science and technology, Heilongjiang Bayi Agricultural University, Daqing 163319, Helongjiang, China and Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China
Abstract:In order to understand the chemical constituents of Aquilaria crassna, ten compounds were isolated from its agarwood. On the basis of spectral data, they were identified as 6,8-dihydroxy-2-(2-phenylethyl)-chromone (1), 6,8-dihydroxy-2-2-(4-methoxyphenyl) ethyl]chromone (2), rel-(1aR,2R,3R,7bS)-1a,2,3,7b-tetrahydro-2,3-dihydroxy-5-(2-phenylethyl)-7H-oxirenof]1]benzopyran-7-one (3), rel-(1aR,2R,3R,7bS)-1a,2,3,7b-tetrahydro-2,3-dihydroxy-2-(4-methoxyphenyl)ethyl]-7H-oxirenof]1]benzopyran-7-one (4), rel-(1aR,2R,3R,7bS)-1a,2,3,7b-tetrahydro-2,3-dihydroxy-5-2-(3-hydroxy-4-methoxyphenyl) ethyl]-7H-oxirenof]1]benzopyran-7-one (5), oxidoagarochromone B (6), oxidoagarochromone C (7), (5S,6R,7S,8R)-2-2-(3''-hydroxy-4''-methoxyphenyl)ethyl]-5,6,7,8-tetrahydroxy-5,6,7,8-tetrahydrochromone (8), 6,7-cis-dihydroxy-2-(2phenylethyl)-5,6,7,8-tetrahydrochromone (9), N-trans-feruloyltyramine (10). Compounds 1-5 and 8-11 were isolated from agarwood of A. crassna for the first time. Compounds 1, 3, 4, 6, 7 and 11 showed inhibitory activities against acetylcholinesterase. Compound 4 had weak inhibitory effect on K-562 and SGC-7901 carcinoma cell lines, and compounds 1 and 3 showed inhibitory activity against BEL-7402 cells.
Keywords:Agarwood  Aquilaria crassna  Chemical constituents  Cytotoxic activity  Acetylcholinesterase inhibitory activity
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