| 见血封喉种子中的强心苷类化合物及其细胞毒活性 |
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| 引用本文： | 董文化,梅文莉,曾艳波,王辉,戴好富.见血封喉种子中的强心苷类化合物及其细胞毒活性[J].热带亚热带植物学报,2011,19(2):171-176. |
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| 作者姓名： | 董文化 梅文莉 曾艳波 王辉 戴好富 |
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| 作者单位： | 1. 海南大学园艺园林学院,海南,儋州,571737;中国热带农业科学院热带生物技术研究所,农业部热带作物生物技术重点开放实验室,海口,571101
2. 中国热带农业科学院热带生物技术研究所海南省黎药资源天然产物研究与利用重点实验室,海口,571101 |
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| 基金项目： | 国家自然科学基金项目(30860345)；中央级公益性科研院所基本科研业务费专项资金(ITBBZD0744) |
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| 摘 要： | 从海南产见血封喉(Antiaris toxicaria (Pers.) Lesch.)种子的乙醇提取物中分离得到7个强心苷类化合物，通过波谱分析(NMR, MS, IR等)，鉴定其结构分别为：杠柳苷元(1)、见血封喉阿洛糖苷(2)、见血封喉去氧阿洛糖苷(3)、毒毛旋花子苷元(4)、毒毛旋花子阿洛糖苷(5)、毒毛旋花子爪哇糖苷(6)和去葡萄糖桂竹香毒苷(7)。化合物7为首次从见血封喉种子中分离得到。细胞毒活性测试结果表明，化合物1~7均对慢性髓原白血病细胞(K562)、人胃癌细胞(SGC-7901)和人肝癌细胞(SMMC-7721)的增殖有较强的生长抑制活性。
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| 关 键 词： | 见血封喉 种子 强心苷 细胞毒活性 |
| 收稿时间： | 2010/8/18 0:00:00 |
| 修稿时间： | 2010/11/2 0:00:00 |
Cardenolides from the Seeds of Antiaris toxicaria and Their Cytotoxicity |
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| DONG Wen-hu,MEI Wen-li,ZENG Yan-bo,WANG Hui and DAI Hao-fu.Cardenolides from the Seeds of Antiaris toxicaria and Their Cytotoxicity[J].Journal of Tropical and Subtropical Botany,2011,19(2):171-176. |
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| Authors: | DONG Wen-hu MEI Wen-li ZENG Yan-bo WANG Hui and DAI Hao-fu |
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| Institution: | DONG Wen-hua1,2,MEI Wen-li2,3,ZENG Yan-bo2,WANG Hui2,DAI Hao-fu2,3*(1.Horticultural and Garden College,Hainan University,Danzhou 571737,China,2.Key Laboratory of Tropical Crop Biotechnology,Ministry of Agriculture,Institute of Tropical Bioscience and Biotechnology,Chinese Academy of Tropical Agricultural Sciences,Haikou 571101,3.Hainan Key Laboratory for Research and Development of Natural Product from Li Folk Medicine,China) |
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| Abstract: | Seven compounds were obtained from the EtOH extract of the seeds of Antiaris toxicaria (Pers.) Lesch. On the basis of spectral analysis (NMR, MS, IR, etc.), their structures were identified as: periplogenin (1), antialloside (2), antiogoside (3), strophanthidin (4), strophalloside (5), strophanthojavoside (6), and desglucocheirotoxin (7). Compound 7 was isolated from the seeds of Antiaris toxicaria for the first time. All of the compounds showed significant inhibitory activities towards chronic myelogenous leukemia (K562), human gastric carcinoma (SGC-7901), and human hepatoma (SMMC-7721) cell lines. |
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| Keywords: | Antiaris toxicaria (Pers ) Lesch Seeds Cardenolides Cytotoxicity |
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