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| 红厚壳枝条的化学成分 | |
| 引用本文： | 魏代静,曾艳波,梅文莉,李小娜,钟惠民,戴好富.红厚壳枝条的化学成分[J].热带亚热带植物学报,2011,19(4):355-359. |
| 作者姓名： | 魏代静 曾艳波 梅文莉 李小娜 钟惠民 戴好富 |
| 作者单位： | 1. 青岛科技大学化学与分子工程学院,山东 青岛 266042;中国热带农业科学院热带生物技术研究所,农业部热带作物生物技术重点开放实验室,海口 571101 2. 中国热带农业科学院热带生物技术研究所,农业部热带作物生物技术重点开放实验室,海口 571101 3. 青岛科技大学化学与分子工程学院,山东 青岛,266042 |
| 基金项目： | 中国热带农业科学院中央级公益性科研院所基本科研业务费专项(ITBBZD0742)资助 |
| 摘 要： | 从红厚壳(Calophyllum inophyllum Linn.)枝条乙醇提取物中分离得到11个化合物,通过光谱分析,鉴定其结构为:6-羟基-2,3-二甲氧基 酮 ( 1 ) ,1,3,7-三羟基 酮 ( 2 ) ,1,3,7-三羟基-8-甲氧基 酮( 3 ) ,7-羟基-1,3-二甲氧基 酮( 4 ) ,伪蒲公英甾醇( 5 ) ,1,3,6-三羟基-5,7-二甲氧基 酮( 6 ) ,2-羟基-1-甲氧基 酮 ( 7 ) ,2-羟基-1,8-二甲氧基 酮 ( 8 ) ,1,3,5-三羟基-2-甲氧基 酮 ( 9 ) ,4-羟基 酮 ( 10 ) ,1,3,5-三羟基 酮 ( 11 ) 。化合物 2 ~ 5 为首次从红厚壳属植物中得到,化合物 6 ~ 8 为首次从该植物中得到,化合物 1 为一新的天然产物。细胞毒活性测试结果表明,化合物 9 对人胃癌细胞(SGC-7901)的增殖显示出生长抑制活性, 其IC50值为1.8×10-5 mol/L。 |
| 关 键 词： | 红厚壳 酮 6-羟基-2 3-二甲氧基酮 细胞毒活性 |
| 收稿时间： | 2010/9/15 0:00:00 |
| 修稿时间： | 2010/12/19 0:00:00 |
Chemical Constituents from the Twigs of Calophyllum inophyllum Linn. |
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| WEI Dai-jing,ZENG Yan-bo,MEI Wen-li,LI Xiao-n,ZHONG Hui-min and DAI Hao-fu.Chemical Constituents from the Twigs of Calophyllum inophyllum Linn.[J].Journal of Tropical and Subtropical Botany,2011,19(4):355-359. | |
| Authors: | WEI Dai-jing ZENG Yan-bo MEI Wen-li LI Xiao-n ZHONG Hui-min and DAI Hao-fu |
| Institution: | College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, China; Key Laboratory of Tropical Crop Biotechnology, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academ;Key Laboratory of Tropical Crop Biotechnology, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences, Haikou 571101, China;Key Laboratory of Tropical Crop Biotechnology, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences, Haikou 571101, China;Key Laboratory of Tropical Crop Biotechnology, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences, Haikou 571101, China;College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, China;Key Laboratory of Tropical Crop Biotechnology, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agriculture Sciences, Haikou 571101, China |
| Abstract: | Eleven compounds were extracted from EtOH extract of the twigs of Calophyllum inophyllum. On the basis of spectroscopic data, their structures were identified as 6-hydroxy-2,3-dimethoxyxanthone ( 1 ) , 1,3,7-trihydroxylxanthone ( 2 ) , 1,3,7-trihydroxy-8-methoxyxanthone ( 3 ) , 7-hydroxy-1,3-dimethoxyxanthone ( 4 ) , pseudo taraxasterol ( 5 ) , 1,3,6-trihydroxy-5,7-dimethoxyxanthone ( 6 ) , 2-hydroxy-1-methoxy-xanthone ( 7 ) , 2-hydroxy-1,8-dimethoxyxanthone ( 8 ) , 1,3,5-trihydroxy-2-methoxyxanthone ( 9 ) , 4-hydroxyxanthone ( 10 ) , and 1,3,5-trihydroxyxanthone ( 11 ) . Compounds 6 - 8 were isolated from this plant for the first time, and compounds 2 - 5 from the genus Calophyllum for the first time. Compound 1 was a new natural product. Compound 9 showed inhibitory activities towards human gastric carcinoma (SGC-7901), with the IC50 value of 1.8×10-5 mol/L. |
| Keywords: | Calophyllum inophyllum Xanthones 6 -hydroxy-2 3-dimethoxyxanthone Cytotoxicity |
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