| 环状RNA的生物学功能及其在肿瘤发生中的作用 |
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| 引用本文： | 谢依,李田文,莫小燕,郭俊明.环状RNA的生物学功能及其在肿瘤发生中的作用[J].生物工程学报,2016,32(11):1507-1518. |
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| 作者姓名： | 谢依 李田文 莫小燕 郭俊明 |
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| 作者单位： | 宁波大学医学院生物化学与分子生物学研究所 浙江省病理生理学技术研究重点实验室，浙江 宁波 315211,宁波大学医学院生物化学与分子生物学研究所 浙江省病理生理学技术研究重点实验室，浙江 宁波 315211,宁波大学医学院生物化学与分子生物学研究所 浙江省病理生理学技术研究重点实验室，浙江 宁波 315211,宁波大学医学院生物化学与分子生物学研究所 浙江省病理生理学技术研究重点实验室，浙江 宁波 315211 |
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| 基金项目： | 浙江省公益技术应用研究计划项目 (No. 2016C33177)，浙江省高等教育教学改革项目 (No. jg2015047) 资助。 |
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| 摘 要： | 近年来,随着RNA研究技术的进步,研究者们在多种生物中发现了数量众多的环状RNA,且发现它们具有重要的生物学功能。环状RNA来源于内含子或外显子,可以充当微小RNA海绵,还能与蛋白质相结合,从而参与基因表达调控并影响蛋白质的功能,此外,个别环状RNA甚至能编码蛋白质。更重要的是,环状RNA在肿瘤(如:胃癌、肝癌、结直肠癌、乳腺癌、宫颈癌和卵巢癌等)的发生和发展过程中起着重要的调控作用。因此,环状RNA有希望成为肿瘤诊断的标志物和治疗的新靶点。
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| 关 键 词： | 环状RNA，微小RNA海绵，肿瘤，发生 |
| 收稿时间： | 2016/3/29 0:00:00 |
Circular RNAs and their roles in tumorigenesis |
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| Yi Xie,Tianwen Li,Xiaoyan Mo and Junming Guo.Circular RNAs and their roles in tumorigenesis[J].Chinese Journal of Biotechnology,2016,32(11):1507-1518. |
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| Authors: | Yi Xie Tianwen Li Xiaoyan Mo and Junming Guo |
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| Institution: | Zhejiang Key Laboratory of Pathophysiology, Department of Biochemistry and Molecular Biology, School of Medicine, Ningbo University, Ningbo 315211, Zhejiang, China,Zhejiang Key Laboratory of Pathophysiology, Department of Biochemistry and Molecular Biology, School of Medicine, Ningbo University, Ningbo 315211, Zhejiang, China,Zhejiang Key Laboratory of Pathophysiology, Department of Biochemistry and Molecular Biology, School of Medicine, Ningbo University, Ningbo 315211, Zhejiang, China and Zhejiang Key Laboratory of Pathophysiology, Department of Biochemistry and Molecular Biology, School of Medicine, Ningbo University, Ningbo 315211, Zhejiang, China |
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| Abstract: | Recently, with the development of RNA research techniques, a wide variety of circular RNAs (circRNAs) have been discovered and some of them are confirmed to have crucial biological functions. CircRNAs arise from exons (i.e. exonic circRNAs) or introns (i.e. intronic circRNAs). Acting as microRNA sponges or combining with proteins, circRNAs participate in the regulation of gene expression and influence the activity of some proteins. In addition, some circRNAs even encode proteins. More importantly, several circRNAs play a key role in the occurrence and progression of some tumors, including stomach, liver, colon, breast, cervical, and ovarian cancers. Therefore, circRNAs may be a novel type of diagnostic marker and therapeutic target of cancers. |
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| Keywords: | circular RNA microRNA sponge tumor occurrence |
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