| 工业生物发酵过程模拟：进展与发展趋势 |
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| 引用本文： | 李德茂,陈吴西,郭蔚,李超峰.工业生物发酵过程模拟：进展与发展趋势[J].生物工程学报,2019,35(10):1974-1985. |
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| 作者姓名： | 李德茂 陈吴西 郭蔚 李超峰 |
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| 作者单位： | 中国科学院天津工业生物技术研究所 天津市工业生物系统与过程工程重点实验室，天津 300308,中国科学院天津工业生物技术研究所 天津市工业生物系统与过程工程重点实验室，天津 300308,中国科学院天津工业生物技术研究所 天津市工业生物系统与过程工程重点实验室，天津 300308,中国科学院天津工业生物技术研究所 天津市工业生物系统与过程工程重点实验室，天津 300308 |
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| 基金项目： | 国家重点研发计划 (No. 2018YFA0902200)，中科院STS计划 (No. KFJ-STS-ZDTP-065)，天津市科技计划 (No. 14ZCZDSY00157) 资助。 |
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| 摘 要： | 工业生物发酵是工业生物技术规模化生产必需的基本操作单元。对微生物细胞及其反应器进行数学模拟将有助于加深对发酵过程的理解,也将为新的合成生物构建提供解决策略。文中对工业发酵系统的特点、数学模拟的发展历史、数学模型的分类和特点、用途等作了深入阐述,并展望了全发酵系统模拟的发展趋势。
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| 关 键 词： | 工业生物技术，发酵，模拟与仿真，机理模型，经验模型，混合模型 |
| 收稿时间： | 2019/6/12 0:00:00 |
Simulation of industrial fermentation: current status and future perspectives |
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| Demao Li,Wuxi Chen,Wei Guo and Chaofeng Li.Simulation of industrial fermentation: current status and future perspectives[J].Chinese Journal of Biotechnology,2019,35(10):1974-1985. |
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| Authors: | Demao Li Wuxi Chen Wei Guo and Chaofeng Li |
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| Institution: | Tianjin Key Laboratory for Industrial Biosystems and Bioprocessing Engineering, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China,Tianjin Key Laboratory for Industrial Biosystems and Bioprocessing Engineering, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China,Tianjin Key Laboratory for Industrial Biosystems and Bioprocessing Engineering, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China and Tianjin Key Laboratory for Industrial Biosystems and Bioprocessing Engineering, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China |
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| Abstract: | Industrial fermentation is the basic operation unit of industrial biotechnology in large-scale production. Mathematical simulation of microbial cells and their reactors will help deepen the understanding of microorganisms and fermentation processes, and will also provide solutions for the construction of new synthetic organisms. In this paper, the characteristics of industrial fermentation system, the development of mathematical simulation, the classification, characteristics and functions of mathematical models are described in depth, and the development trend of whole fermentation system simulation is prospected. |
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| Keywords: | industry biotechnology fermentation modeling and simulation mechanistic model empirical model hybrid model |
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