| 成纤维细胞直接重编程为心肌细胞研究进展 |
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| 引用本文： | 徐正燕,李鹰.成纤维细胞直接重编程为心肌细胞研究进展[J].生物工程学报,2017,33(7):1069-1074. |
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| 作者姓名： | 徐正燕 李鹰 |
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| 作者单位： | 首都医科大学附属北京朝阳医院医学研究中心，北京 100020,首都医科大学附属北京朝阳医院医学研究中心，北京 100020 |
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| 基金项目： | 国家自然科学基金 (No. 31440062) 资助。 |
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| 摘 要： | 心肌细胞的再生疗法作为心脏疾病的新型疗法受到人们的广泛关注。细胞直接重编程技术为诱导获得心肌细胞提供了新的方法,它可以绕过多潜能的阶段,将一种终末分化的细胞直接重编程为心肌细胞,为将来细胞移植提供更为安全的细胞来源。文中对体内外直接重编程成纤维细胞为心肌细胞的研究方法及其存在的问题进行了总结,并对心肌细胞直接重编程的未来发展进行展望。
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| 关 键 词： | 成纤维细胞，直接重编程，心肌细胞 |
| 收稿时间： | 2016/12/22 0:00:00 |
Direct reprogramming from fibroblasts into cardiamyocytes |
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| Zhengyan Xu and Ying Li.Direct reprogramming from fibroblasts into cardiamyocytes[J].Chinese Journal of Biotechnology,2017,33(7):1069-1074. |
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| Authors: | Zhengyan Xu and Ying Li |
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| Institution: | Medical Research Center, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China and Medical Research Center, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China |
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| Abstract: | Cardiac regenerative therapy has attracted much attention as a novel approach for heart diseases. Direct reprogramming of fibroblasts into cardiomyocytes without going through a pluripotent stem cell stage would provide a promising source of cells for cell transplantation in future. This review summarizes the research methods and problems of direct reprogramming of fibroblasts into cardiomyocytes in vitro and in vivo, and forecasts the future development of this new strategy. |
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| Keywords: | fibroblasts direct reprogramming cardiomyocytes |
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